Molecular and Immunological Analyses of the Borrelia turicatae Bdr Protein Family
- 1 April 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (4) , 2369-2373
- https://doi.org/10.1128/iai.68.4.2369-2373.2000
Abstract
Here, we describe the molecular and immunological characterization of the bdr gene family of Borrelia turicatae , a relapsing-fever spirochete. Nine bdr alleles belonging to two different subfamilies were sequenced and localized to linear plasmids. Anti-Bdr antiserum was generated and used to analyze Bdr expression in pre- and postinfection isogenic populations. The analyses presented here provide a detailed characterization of the Bdr proteins in a relapsing-fever spirochete species, enhancing our understanding of these proteins at the genus-wide level.Keywords
This publication has 25 references indexed in Scilit:
- The bdr Gene Families of the Lyme Disease and Relapsing Fever Spirochetes: Potential Influence on Biology, Pathogenesis, and EvolutionEmerging Infectious Diseases, 2000
- Molecular and Evolutionary Characterization of the cp32/18 Family of Supercoiled Plasmids in Borrelia burgdorferi 297Infection and Immunity, 2000
- Mutation and Recombination in the Upstream Homology Box-Flanked ospE -Related Genes of the Lyme Disease Spirochetes Result in the Development of New Antigenic Variants during InfectionInfection and Immunity, 2000
- Evolutionary and molecular analyses of the Borrelia bdr super gene family: Delineation of distinct sub-families and demonstration of the genus wide conservation of putative functional domains, structural properties and repeat motifsMicrobial Pathogenesis, 2000
- The serine, threonine, and/or tyrosine-specific protein kinases and protein phosphatases of prokaryotic organisms: a family portraitFEMS Microbiology Reviews, 1998
- Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologueMolecular Microbiology, 1995
- Borrelia burgdorferi genes selectively expressed in the infected host.Proceedings of the National Academy of Sciences, 1995
- Variability of a bacterial surface protein and disease expression in a possible mouse model of systemic Lyme borreliosis.The Journal of Experimental Medicine, 1994
- Transcriptional start and MetR binding sites on the Escherichia coli metH geneBiochemical and Biophysical Research Communications, 1991
- Borrelia burgdorferi sp. nov.: Etiologic Agent of Lyme DiseaseInternational Journal of Systematic and Evolutionary Microbiology, 1984