Rheumatoid Factors and Rheumatoid Arthritis
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Rheumatology
- Vol. 17 (sup74) , 41-44
- https://doi.org/10.3109/03009748809102938
Abstract
Rheumatoid factors (RFs) are autoantibodies which bind the Fc region of IgG (1, 2). They can be induced in experimental animals by B cell mitogens and by immunization with a variety of different antigens. Induction by the antigen-driven route has been accomplished only in secondary but not in primary immunization, suggesting that RFs arise as a response occasioned by antigenlantibody-complex rather than the antigen alone.Keywords
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