Influence of Fibrinogen Degradation Products (FDP) on the Central Nervous System and on the Effects of Centrally Acting Drugs
- 1 January 1975
- journal article
- Published by S. Karger AG in Pharmacology
- Vol. 13 (3) , 252-259
- https://doi.org/10.1159/000136912
Abstract
Fibrinogen degradation products (FDP) from bovine fibrinogen were obtained in vitro by trypsin digestion for 3 and 120 min, respectively. FDP-120 min applied i.p. and i.v.c. stimulated the CNS, while FDP-3 min did not. The FDP increased the potency of amphetamine, caffeine, thiopental, and chlorpromazine by enhancing their level in the brain. Peptides from 120 min digestion were more effective. A possible mechanism of observed changes has been discussed.Keywords
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