The Enantioselective Synthesis of α-Amino Acid Derivatives via Organoboranes
- 19 July 2002
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 124 (32) , 9348-9349
- https://doi.org/10.1021/ja017522e
Abstract
Optically active (S)-α-amino acids are prepared in 54−95% ee (12 cases) by reaction of the Schiff base acetate of glycine tert-butyl ester with B-alkyl-9-BBN derivatives in the presence of the Cinchona alkaloid, cinchonidine, and base. The enantiomeric (R)-α-amino acids are available in 59−92% ee (3 cases) by using cinchonine as the chiral control element.Keywords
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