Evaluation of Testicular Function by Measurement of Urinary Excretion of Testosterone

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Abstract
The excretory values of testosterone were determined in normal, castrated and adrenalectomized men before and during stimulation with ACTH [adrenocorticotropic hormone] and HCG [human chorionic gonadotropin] and suppression with dexamethasone. The normal men responded to HCG stimulation with a mean testosterone excretion 2 1/2 times that of the control values. When stimulated with ACTH these subjects increased testosterone excretion by 35%. Suppression with dexamethasone diminished testosterone in the same order of magnitude. The orchiectomized patients had much lower basal testosterone excretion values than normal males. One patient showed no response to HCG above the control value, while the remaining 2 patients increased testosterone excretion slightly. The administration of ACTH produced an increment of testosterone that reached an average of 128%.