Curcacycline A — a novel cyclic octapeptide isolated from the latex of Jatropha curcas L
- 30 January 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 358 (3) , 215-218
- https://doi.org/10.1016/0014-5793(94)01405-p
Abstract
From the latex of Jatropha curcas L. (Euphorbiaceae) a novel cyclic octapeptide was isolated, which we named curcacycline A. The compound was found to contain one threonine, one valine, two glycine, and four leucine residues. By two-dimensional 1H-NMR spectroscopy (HOHAHA and ROESY), its sequence was determined to be Gly1-Leu2-Leu3-Gly4-Thr5-Val6-Leu7-Leu8-Gly1+ ++. Curcacycline A displays a moderate inhibition of (i) classical pathway activity of human complement and (ii) proliferation of human T-cells.Keywords
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