STEVENS-JOHNSON SYNDROME, A VARIATION OF ERYTHEMA MULTIFORME EXSUDATIVUM (HEBRA): A REPORT OF TWO CASES

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Abstract
Stevens and Johnson in 1922 felt that their syndrome of an eruptive febrile disease associated with stomatitis and purulent conjunctivitis was a distinct clinical entity. Controversy exists, however, as to whether the syndrome should be differentiated from erythema multiforme exsudativum. Tow cases of this rare syndrome were admitted to the same service within a period of 1 mo. during the mild influenza epidemic of 1945. The first case was that of a 37 yr. old white [male] who exhibited generalized toxicity, ulcerative membranous stomatitis, purulent ophthalmia, urethritis, albuminuria and casts, bronchopneumonia with hilar gland enlargement, nose bleeding, polymorphonuclear leucocytosis. The duration was 20 days. The 2d case was that of a [male], age 11, who exhibited an eruptive bullous type febrile disease associated with stomatitis, ophthalmia, bronchopneumonia with hilar gland enlargement. The duration was 17 days. Both cases recovered. They were treated with penicillin and local measures; in comparison with the outcome of the published cases, the effect of penicillin was not remarkable although it no doubt was effective treatment for the pneumonia. The purulent conjunctivitis is the alarming symptom. The disease seems to be the expression of a systemic infection. The etiology is unknown.

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