New platelet aggregation inhibitors from Tan-Shen; Radix of Salvia miltiorrhiza Bunge.

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Abstract
A potent inhibitor (Ro 09-0680) of rabbit platelet aggregation induced by collagen was isolated from a Chinese medicine, Tan-Shen, (radix of Salvia miltiorrhiza) and identified as a novel component, 2-isopropyl-8-methylphenanthrene-3,4-dione (I). IC50 [median inhibitory concentration] of I in the previously established assay was 6.6 .times. 10-6 M, which is 30 times more potent than papaverine. Related diketophenanthrene derivatives such as tanshinone I, tanshinone II and cryptotanshinone had inhibitory activity, though to a lesser extent.