Effect of somatostatin on plasma renin activity.

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Abstract
I.v. infusion of somatostatin [S] in mongrel dogs caused a significant decrease in the peripheral plasma renin activity (PRA) enhanced by pentobarbital sodium anesthesia or furosemide treatment. However, the inhibitory activity vanished within 10 min after termination of S infusion. Intrarenal arterial infusion of S decreased furosemide-enhanced PRA in renal vein by 24.0%, 16.6% and 8.6% in dose of 0.1, 0.5 and 1.0 .mu.g, respectively. High doses of the peptide (50-200 .mu.g) failed to decrease. The changes in PRA occurred in the absence of any alteration in blood pressure during the i.v. infusion under furosemide treatment. In an in vitro study, the addition of S in doses of 0.01 and 0.05 .mu.g suppressed the renin release in dog renal cortical cell suspension by 74.3% and 53.6%, respectively. Therefore, in both intrarenal arterial infusion and the cell suspension system, S was increasingly effective in decreasing renin release towards the lower end of the dose range tested. The effect of S on hyperreninemia may involve an inhibition of renin release at the cell level in the kidney.

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