Electroconvulsive therapy for iatrogenic hypothalamic-hypopituitarism (CRF-ACTH type)

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Abstract
A 41 yr old man with hypothalamic hypopituitarism that persisted for 2 yr after discontinuation of exogenous dexamethasone was treated with bilateral ECT [electroconvulsive therapy] for severe chronic depression. The depression cleared completely and permanently, based on responses to 4 metyrapone stress tests in a 2 yr follow-up period. ECT may be an effective treatment for persistent hypothalamic-pituitary suppression, even in the absence of a psychiatric disorder.