Mechanism of Hardness of Aged Compacts

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Abstract
The hardness changes in aged compacts of the chloride, bromide and iodide salts of sodium, potassium and ammonium, stored at various relative humidities, were studied. The effect of moisture on hardness followed a parabolic curve. Hardness increased with increasing moisture content, reached a maximum value in the region of deliquescence and then decreased drastically as the salt deliquesced. The incorporation of moisture in the starting material resulted in compacts with a pronounced decrease in strength. However, no further significant hardness changes were observed on aging. Addition of lubricants drastically reduced tablet hardness, and significantly reduced the hardening on aging.