ANTICONFLICT PROPERTIES OF THE DIPEPTIDE LITORALON AND OF DIAZEPAM IN RATS

  • 1 January 1986
    • journal article
    • research article
    • Vol. 67  (3) , 331-338
Abstract
The anticonflict properties of the anxiolytic diazepam and of the dipeptide LitoralonR .gamma.-L-glutamyl-taurine and two of its analogues SZJ 3388, .gamma.-aminobutyrylethanolamine phosphate, and SZJ 3361, D-1-aminoisobutyrylethanolamine phosphate have been investigated in a "time-to-emerge" conflict paradigm in non-deprived rats. Diazepam, LitoralonR and compound SZJ 3388 significantly decreased the "time-to-emerge" latency (TTE latency) in a dose-dependent manner versus saline- or vehicle-treated controls in doses between 0.05 and 0.50 mg/kg intraperitoneally. The analogue SZJ 3361 was inactive as regards the TTE latency, while the anti-histaminic promethazine lengthened the TTE latency in a dose-dependent manner. The number of irresolute responses was significantly decresed following administration of diazepam, SZJ 3388 and LitoralonR and was positively correlated with the TTE latency-decreasing activity of these compounds. The data are discussed in terms of the benzodiazepine-like anxiolytic or anticonflict properties of these dipeptides.

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