Assay and Characterization of the Factor in Porcine and Bovine Plasma which Aggregates Human Platelets

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Abstract
The technique is based on direct measurement of platelet aggregation using an electronic particle counter. Using this assay it was established that platelet aggregating activity is present in both bovine and porcine plasma and in therapeutic concentrates of factor VIII prepared from these materials. Platelet aggregating activity was a function of the factor-VIII-related antigen concentration and independent of factor-VIII coagulant activity. The activity is absent in the plasma from pigs with von Willebrand''s disease. Factor-VIII-related antigen and the platelet aggregating factor are apparently closely related and may represent 1 protein species.