Glucocorticoids modulate mRNA levels for G-protein β-subunits
- 15 May 1989
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 260 (1) , 271-275
- https://doi.org/10.1042/bj2600271
Abstract
Adrenalectomy decreases, whereas glucocorticoid treatment increases, the steady-state levels of G-protein beta-subunits (G beta) in rat fat-cells. A DNA-excess solution-hybridization assay was established to define the steady-state mRNA levels for G beta [5.8 +/- 0.4 amol/micrograms of RNA (n = 5) in control fat-cells]. G beta mRNA levels decrease by 20% after adrenalectomy; dexamethasone treatment reverses the decline. Dexamethasone treatment itself increases G beta mRNA levels by 50%.This publication has 7 references indexed in Scilit:
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