Target-Cell-Specific Left-Right Asymmetry of NMDA Receptor Content in Schaffer Collateral Synapses in ϵ1/NR2A Knock-Out Mice

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Abstract
Input-dependent left-right asymmetry of NMDA receptor ϵ2 (NR2B) subunit allocation was discovered in hippocampal Schaffer collateral (Sch) and commissural fiber pyramidal cell synapses (Kawakami et al., 2003). To investigate whether this asymmetricalϵ2 allocation is also related to the types of the postsynaptic cells, we compared postembedding immunogold labeling for ϵ2 in left and right Sch synapses on pyramidal cells and interneurons. To facilitate the detection of ϵ2 density difference, we used ϵ1 (NR2A) knock-out (KO) mice, which have a simplified NMDA receptor subunit composition.