Hepatocellular carcinoma: MR imaging with mangafodipir trisodium (Mn-DPDP).
- 1 July 1996
- journal article
- clinical trial
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 200 (1) , 69-77
- https://doi.org/10.1148/radiology.200.1.8657947
Abstract
PURPOSE: To determine the efficacy of manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (DPDP) at magnetic resonance (MR) imaging for evaluation of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: MR imaging at 1.5 T was performed in 20 patients with 65 HCC nodules. T1- and T2-weighted spin-echo and T1-weighted gradient-recalled-echo images were obtained before and after administration of 5 mumol/kg Mn-DPDP. Readers individually evaluated the pre- and postcontrast images for detection of tumor nodules, with subsequent consensus reading for interpretation discrepancies. Quantitative measurements of tumor-liver contrast-to-noise ratio (C/N) were also performed. Enhancement characteristics were correlated with histologic tumor differentiation. RESULTS: Precontrast images depicted 50 lesions in 17 patients, and postcontrast images depicted 49 lesions in 20 patients. Combination of pre- and postcontrast images enabled detection of 53 lesions in 20 patients. Three lesions (...Keywords
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