Amyloid in basal cell carcinomas

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Abstract
Stromal or intratumor deposits of amyloid were found in 30 of 46 randomly selected [human] basal cell carcinomas. Amyloid was found less often in histologically aggressive tumors than in other sub-types. Immunoglobulins [Ig], predominantly IgM, were demonstrated in all but 1 of these 30 cases, corresponding to the distribution of amyloid deposits. EM revealed early amyloid in 1 case which showed numerous stromal IgM bodies on immunofluorescence but no evidence of amyloid by routine histochemical methods.

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