Human Pancreatic Growth Hormone (GH)-Releasing Hormone Stimulates GH Synthesis and Release in Infant Rats. Anin vivoStudy*

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Abstract
Administration of human pancreatic GH[growth hormone]-releasing factor 1-40 (hpGRF-40) at doses of 1, 10, 20, 100 and 500 ng/100 g BW [body wt] s.c. induced in 10 day old rats a clear-cut rise in plasma GH 15-min post injection, although the effect was not dose-related and peak GH levels were already present after the lowest GRF dose. In 25 day old rats, hpGRF induced only a slight rise in plasma GH at the dose of 500 ng/100 g BW s.c.; it was completely ineffective at the lower doses. In 5 day old rats, hpGRF (20 ng/100 g BW s.c. twice daily), administered for 5 days, induced a marked rise in pituitary GH content and plasma GH levels determined 14 h after the last hpGRF injection. In these rats, at the end of treatment, a challenge hpGRF dose (20 ng/100 g BW) induced a rise in plasma GH significantly higher than in infant rats receiving only the challenge hpGRF dose. Pituitary responsiveness to hpGRF is strikingly higher in infant than in postweaning rats. In infants rats, subacute administration of hpGRF stimulates GH synthesis and release.

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