Selective formation of hydrogen bonded cocrystals between a sulfonamide and aromatic carboxylic acids in the solid state
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- No. 12,p. 2213-2216
- https://doi.org/10.1039/p29950002213
Abstract
Co-grinding sulfadimidine [4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide] with several aromatic carboxylic acids in the solid state produces 1 : 1 hydrogen bonded cocrystals which are identical to those obtained from reaction between the components in solution. The kinetics of solid state formation of selected cocrystals have been measured using X-ray powder diffraction. Sulfadimidine selectively cocrystallizes with 2-aminobenzoic acid when the latter is present in binary mixtures of acids. Solid state reaction of the cocrystal sulfadimidine·2-hydroxybenzoic acid with 2-aminobenzoic acid results in elimination of 2-hydroxybenzoic acid and formation of the cocrystal sulfadimidine·2-aminobenzoic acid.Keywords
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