Phenytoin elimination kinetics in two children with drug intoxication
- 1 October 1980
- journal article
- research article
- Published by Springer Nature in European Journal of Pediatrics
- Vol. 135 (1) , 69-71
- https://doi.org/10.1007/bf00445896
Abstract
Two girls aged 6 and 10 years treated with anticonvulsants developed nystagmus and ataxia. The peak plasma concentrations of phenytoin were 42.6 and 46.6 μg/ml, respectively, compatible with phenytoin toxicity. The decline in plasma phenytoin levels did not fit first order kinetics, but followed Michaelis-Menten kinetics.Keywords
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