Contact sensitivity to acrylate compounds in guinea pigs

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Abstract
As reports of contact dermatitis in humans due to acrylate compounds have increased considerably in recent years, it was decided to investigate the ability of these chemicals to evoke contact sensitivity skin reactions in guinea pigs. Acrylate and methacrylate compounds (21) were scanned for their ability to induce contact sensitivity, using 5 different sensitization protocols. Contact reactions of varying intensities were produced to all the mono-, di- and triacrylates tested. It was not possible to sensitize guinea pigs to any methacrylates. Guinea pigs apparently cannot be contact sensitized to acrylate chemicals that are substituted on carbon 2.