Inhibition of Theophylline Elimination in Rabbits by Verapamil
- 1 April 1989
- journal article
- research article
- Published by Wiley in Basic & Clinical Pharmacology & Toxicology
- Vol. 64 (4) , 349-351
- https://doi.org/10.1111/j.1600-0773.1989.tb00662.x
Abstract
Single intravenous dose pharmacokinetics of theophylline in 10 rabbits were investigated before and after 5 days oral administration of verapamil in daily doses of 6 mg/kg. Verapamil caused a significant inhibition of theophylline elimination. Theophylline clearance was reduced from 126 to 98 ml/hr/kg (22.2%) whereas the steady state volume of distribution of the drug increased from 461 to 550 ml/kg (19.3%). The terminal half‐life of theophylline increased from 2.7 to 4.0 hr (49.8%).This publication has 10 references indexed in Scilit:
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