HPLC Determination of Lactic Acid in Milrinone Injection and Oral Solution Using Ion-Exchange Sample Preparation Methods

1 July 1985

journal article
research article
Published by Taylor & Francis in Journal of Liquid Chromatography

Vol. 8 (9) , 1629-1650
https://doi.org/10.1080/01483918508074083

Abstract

Lactic acid has been measured in Milrinone Injection and Oral Solution by HPLC using an ion-exclusion polymeric column coupled with a reversed-phase guard column. This dual-column chromato-graphy was preceded by classical ion-exchange sample preparation to eliminate interfering excipient components. The lactic acid lactate content of USP lactic acid was converted to lactic acid in processing. It was also further characterized using a TLC separation.

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