Parity, tubal sterilization, hysterectomy and risk of primary fallopian tube carcinoma in Finland, 1975–2004

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Abstract
We studied the possible relationship among parity, female sterilization, hysterectomy and the risk of primary fallopian tube carcinoma (PFTC) in a case–control study in Finland in cases occurring between 1975 and 2004. A total of 573 PFTC cases were identified from the Finnish Cancer Registry, and10 age-matched controls per case were randomly selected from the Finnish Central Population Registry. In multivariate analysis (including 189 PFTC cases and 1764 controls) parity was protective: the odds ratio (OR) for 1–2 deliveries was 0.63 (95% CI 0.44–0.91) and for ≥3 deliveries, 0.32 (95% CI 0.19–0.52). The OR for sterilization was 0.74 (95% CI 0.42–1.30) and for hysterectomy 1.27 (95% CI 0.73–2.21). Our findings suggest a possible hormonal background as regards the development of PFTC.