Sequential and differing nitroreductive pathways for mutagenic nitropyrenes in Salmonella typhimurium

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Abstract
The nitro group of nitropyrenes is required for mutagenicity in Salmonella typhimurium. 1-Nitropyrene and 1, 3-dinitro-pyrene are reduced by the ‘classical’ nitroreductase, which involves a single electron transfer, while the reduction of the first nitro group of 1, 6- and 1, 8-dinitropyrene proceeds by a two-electron transfer mechanism and involves a different enzyme. However, reduction of the second nitro group, which is not necessary for the mutagenicity of nitropyrenes but is required for the mutagenicity of aminonitropyrenes, is catalyzed by the ‘classical’ nitroreductase.