Influence of Certain Additives on the Photostability of Physosticmine Sulfate Solutions

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Abstract
Certain chemicals belonging to different groups of pharmaceutical adjuvants such as antioxidants, chelating agents, tonicity adjustors, photoprotective agents, buffer salts and preservatives were evaluated as stabilizing agents against photodegradation of physostigmine sulfate solutions in acetate buffer of pH 4.5. Of the materials studied, sodium benzoate appeared to be most effective, followed by potassium acid phthalate and then tartaric acid. Uric acid, sodium thiosulfate and glycerin were less effective. On the other hand, boric acid and sodium metabisulfite demonstrated the least photostabilizing action.

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