HIV entry inhibition by the envelope 2 glycoprotein of GB virus C
- 12 March 2007
- journal article
- Published by Wolters Kluwer Health in AIDS
- Vol. 21 (5) , 645-647
- https://doi.org/10.1097/qad.0b013e32803277c7
Abstract
Epidemiological studies have revealed an association between GB virus C (GBV-C) long-term viraemia and ameliorated HIV disease progression. We have provided evidence that a single protein of GBV-C, the glycoprotein E2, interferes with early HIV replication steps of both X4- and R5-tropic HIV strains. Preincubation with anti-E2 antibody specifically abrogates the inhibitory effect. Results were confirmed by the in-vitro expression of GBV-C E1/E2 encoding RNA.Keywords
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