INTERACTION BETWEEN FIBROBLASTS, LIPOPROTEINS AND 3 ANTI-LIPOPROTEINS IGA-KAPPA

  • 1 January 1980
    • journal article
    • research article
    • Vol. 39  (2) , 455-460
Abstract
Human low density lipoproteins [LDL] are metabolized by cultured human fibroblasts through a specific metabolic pathway which entails the regulation of intracellular cholesterol synthesis. When anti-lipoprotein Ig[immunoglobulin]A coming from patients with myeloma, mixed hyperlipidemia and xanthomatosis were introduced into the system, a decrease of the protein degradation of the LDL molecule and a disappearance of the regulation of intracellular cholesterol synthesis were observed. In the same system, an anti-lipoprotein IgA from a case of myeloma with mixed hyperlipidemia but without xanthomatosis or control IgG and IgA were inactive and did not modify the LDL pathway.