Triglyceride alterations in normal and reticuloendothelial stimulated rats following carbon tetrachloride

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Abstract
The administration of a single dose of carbon tetrachloride to normal rats was associated with a significant increase in liver triglyceride concentration and a pronounced reduction in plasma triglycerides. The evaluation of hepatic activity indicated that the removal of bromsulphalein from plasma was significantly impaired while phagocytic function remained unaltered. Animals with pronounced hyperplasia and hyperfunction of the reticulo‐endothelial system induced by zymosan were less susceptible to carbon tetrachloride, manifesting a smaller degree of liver triglyceride accumulation and maintenance of a normal plasma triglyceride level. The possible significance of these findings are discussed.