Susceptibility to Carcinogenesis at Different Ages

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Abstract
A rapid increase in incidence with age is characteristic of most types of cancer; but it is not universal and cancer cannot be regarded as a direct result of ageing. Animal experiments made to discover if susceptibility to cancer induction varies with age have given conflicting results and the human data are difficult to interpret. It is easier to induce cancer by irradiation in the infant''s thyroid than in the adult, but different results are observed for other types of cancer. Following the Hiroshima atomic bomb explosion, the incidence of leukemia has been equal at all ages; but the incidence of other types of cancer appears to have increased with age. In Britain the incidence of leukemia among irradiated spondylitics and of three types of industrial cancer have all increased with increasing age at first exposure. It is suggested that atissue''s susceptibility to cancer induction depends inpart on the extent of its past exposure to other factors.

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