Nephrotic Syndrome in Ulcerative Colitis

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Abstract
Complicating disorders in various organs outside the intestinal tract are common in ulcerative colitis. The occurrence of nephrotic syndrome in 2 patients with long-standing ulcerative colitis was studied. In the patient studied in most detail, 2 episodes took place, the 1st developing into uremia. After colectomy, rapid improvement of renal function took place. The morphological changes in kidney biopsies were compatible with the presence of focal glomerular sclerosis. Activity in the complement system and a favorable response to steroid treatment indicated that humoral immune mechanisms were of pathogenetic importance with regard to the renal disease in these 2 patients. Nephrotic syndrome was not previously described as a complication to ulcerative colitis.