The effect of dithiothreitol on the LW antigen

12 November 1984

journal article
research article
Published by Wiley in Transfusion

Vol. 24 (6) , 536-537
https://doi.org/10.1046/j.1537-2995.1984.24685066821.x

Abstract

Dithiothreitol (DTT) has been found to destroy the integrity of the LW antigen. This may pose a problem when DTT is used to differentiate IgM from IgG anti-LW, or may be used as an aid in the identification of anti-LW.

Keywords

This publication has 13 references indexed in Scilit:

Disulfide bonds are a requirement for Kell and Cartwright (Yt^a) blood group antigen integrity
British Journal of Haematology, 1983
Disulfide bonds are a requirement for Kell and Cartwright (Yt^a) blood group antigen integrity
British Journal of Haematology, 1983
The mode of attenuation of erythrocyte membrane Rh0(D) antigen activity by 5,5'-dithiobis-(2-nitrobenzoic acid) and protection against loss of activity by bound anti-Rh0(D) antibody☆
Molecular Immunology, 1983
A ‘New’ Allele Giving Further Insight into the LW Blood Group System
Vox Sanguinis, 1982
Optimal Conditions for the Use of Sulphydryl Compounds in Dissociating Red Cell Antibodies
Vox Sanguinis, 1976
A New Example of Anti‐LW and Further Studies on Heterogeneity of the System
Transfusion, 1975
Maternal Anti‐LW
Transfusion, 1971
A Complex Serological Investigation Involving LW
Vox Sanguinis, 1967
Erythrocyte membrane sulfhydryl groups and Rh antingen activity
Immunochemistry, 1967
Third Example of a Human “D‐like” Antibody or Anti‐LW
Transfusion, 1964