Anthrax toxin: a tripartite lethal combination1
- 29 October 2002
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 531 (3) , 384-388
- https://doi.org/10.1016/s0014-5793(02)03609-8
Abstract
Anthrax is a severe bacterial infection that occurs when Bacillus anthracis spores gain access into the body and germinate in macrophages, causing septicemia and toxemia. Anthrax toxin is a binary A-B toxin composed of protective antigen (PA), lethal factor (LF), and edema factor (EF). PA mediates the entry of either LF or EF into the cytosol of host cells. LF is a zinc metalloprotease that inactivates mitogen-activated protein kinase kinase inducing cell death, and EF is an adenylyl cyclase impairing host defences. Inhibitors targeting different steps of toxin activity have recently been developed. Anthrax toxin has also been exploited as a therapeutic agent against cancer.Keywords
This publication has 46 references indexed in Scilit:
- Anthrax ToxinRCSB Protein Data Bank, 2002
- Bioterrorism-Related Inhalational Anthrax: The First 10 Cases Reported in the United StatesEmerging Infectious Diseases, 2001
- AnthraxAnnual Review of Microbiology, 2001
- Dominant-Negative Mutants of a Toxin Subunit: An Approach to Therapy of AnthraxScience, 2001
- Point Mutations in Anthrax Protective Antigen That Block TranslocationJournal of Biological Chemistry, 2001
- Anthrax ToxinCritical Reviews in Microbiology, 2001
- Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNγ‐induced release of NO and TNFαFEBS Letters, 1999
- AnthraxNew England Journal of Medicine, 1999
- Anthrax Lethal Factor Cleaves the N-Terminus of MAPKKs and Induces Tyrosine/Threonine Phosphorylation of MAPKs in Cultured MacrophagesBiochemical and Biophysical Research Communications, 1998
- The vacuolar ATPase proton pump is required for the cytotoxicity of Bacillus anthracis lethal toxinFEBS Letters, 1996