DIAGNOSIS AND TREATMENT OF ACQUIRED HEMOLYTIC ANEMIA

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Abstract
In the early years of this century several French workers1described a form of hemolytic anemia in which autoagglutination of the patient's red blood cells was frequently observed and a circulating hemolysin often demonstrable. This entity was described as acquired hemolytic anemia to distinguish it from the congenital variety. The concept did not receive widespread acceptance for a number of years, and many such cases were undoubtedly misclassified as hereditary hemolytic anemias. In 1938, Dameshek and associates2demonstrated that hemolytic anemias of varying degrees of severity could be experimentally produced by the injection of anti-red-blood-cell serums. The erythrocytes of animals so treated became spherocytic, a characteristic previously considered pathognomonic for the congenital type of hemolytic anemia. Nevertheless, until some seven years ago the demonstration of anti-red-blood-cell antibodies in human beings with hemolytic anemia was possible in only a fraction of the cases. The introduction of new techniques, derived

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