Monomethylthio analogs of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane
- 1 October 1977
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (10) , 1235-1239
- https://doi.org/10.1021/jm00220a001
Abstract
Regiospecific syntheses of the three monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane are described. The three isomeric amines were evaluated for potential psychotomimetic potency using the rabbit hyperthermia assay. Enantiomeric compositions and time-concentration curves in rat brains were determined following intraperitoneal administration of each compound. The biological data are contrasted with the corresponding results obtained with the potent human psychotogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM).Keywords
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