PLASMA, CARDIAC TISSUE AND BRAIN MORPHINE CONCENTRATIONS IN ACUTE AND CHRONIC MORPHINE-TREATED RATS
- 1 February 1989
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 16 (2) , 117-120
- https://doi.org/10.1111/j.1440-1681.1989.tb01535.x
Abstract
1. The plasma, cardiac tissues and brain morphine concentrations in rats after acute or chronic morphine treatment were measured by high-performance liquid chromatography. 2. Morphine concentrations in plasma and cardiac tissues were found to be significantly higher than those in brain after acute morphine injection. However, after chronic oral administration, morphine concentrations in plasma, cardiac tissues and brain were similar. 3. Brain concentrations of morphine following chronic administration were higher than those obtained after acute administration although concentrations in plasma and cardiac tissues were lower.Keywords
This publication has 9 references indexed in Scilit:
- INFLUENCE OF ACUTE MYOCARDIAL ISCHAEMIA ON VENTRICULAR CYCLIC AMP CONCENTRATIONS IN NAIVE AND MORPHINE‐TREATED RATSClinical and Experimental Pharmacology and Physiology, 1988
- Ventricular histamine concentrations in naive and morphine-treated rats during acute myocardial ischaemiaInflammation Research, 1988
- Ventricular noradrenaline concentrations in naïve and morphine-treated rats subjected to acute myocardial ischaemiaBritish Journal of Pharmacology, 1988
- CARDIOVASCULAR RESPONSES TO ACUTE MYOCARDIAL ISCHAEMIA IN MORPHINE‐DEPENDENT RATSClinical and Experimental Pharmacology and Physiology, 1988
- Production of physical dependence in rats by drinking a morphine solutionPharmacology Biochemistry and Behavior, 1986
- Plasma and CSF morphine concentrations after i.m. and epidural administrationPharmacological Research Communications, 1985
- Brain and plasma concentrations of morphine during the development of physical dependence and toleranceJournal of Pharmacy and Pharmacology, 1976
- Quantitative determination of morphine in biological samples by gas-liquid chromatography and electron-capture detectionJournal of Pharmacy and Pharmacology, 1975
- Analgesic Action and Brain and Plasma Levels of Morphine and Codeine in Morphine Tolerant, Codeine Tolerant and Non‐Tolerant RatsActa Pharmacologica et Toxicologica, 1964