Enzymatic synthesis of a new type of penicillin
- 1 January 1986
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 12,p. 975-976
- https://doi.org/10.1039/c39860000975
Abstract
A new antibacterial penicillin, containing a 2-α-methoxy group, has been obtained by enzymatic synthesis from the tripeptide δ-(L-α-aminoadipoyl)-L-cysteinyl-D-(O-methyl-allothreonine) with isopenicillin N synthetase derived from Cephalosporium acremonium CO 728[δ-(L-α-aminoadipoyl)= 5-(5S)-amino-5-carboxypentanoyl].Keywords
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