BRAIN-TYPICAL CREATINEKINASE IN THE SERUM OF NEWBORN INFANTS WITH PERINATAL BRAIN DAMAGE
- 1 March 1978
- journal article
- research article
- Published by Wiley in Acta Paediatrica
- Vol. 67 (2) , 177-180
- https://doi.org/10.1111/j.1651-2227.1978.tb16299.x
Abstract
The normal values of serum-CK[creatinekinase]-activity in healthy newborns varied greatly (95% range: 4-165 U/l; 257 probands) and the borderline to pathological values was not sharp. Brain-typical CK-isoenzyme (CK-BB) could be detected in the serum of 6 of 8 infants with perinatal brain damage by means of agar gel electrophoresis. The combination of neuropathological symptoms, increased total-serum-CK-activity, and significant amount of CK-BB in serum seemed to be a sure sign of severe CNS-damage in newborns.Keywords
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