Potential anticonvulsants. 11. Synthesis and anticonvulsant activity of spiro[1,3-dioxolane-2,3'-indolin]-2'-ones and structural analogs
- 1 May 1988
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 31 (5) , 1001-1005
- https://doi.org/10.1021/jm00400a018
Abstract
A number of spiro[1,3-dixolane-2,3''-indolin]-2''-ones were synthesized and tested for anticonvulsant activity in the maximal electroshock seizure (MES) and pentylenetetrazole seizure threshold (sc-Met) tests. 5''-Chlorospiro[1,3-dioxolane-2,3''-indolin]-2''-one was the most active compound in the MES test and had ED50 = 27.97 mg/kg. Structural analogues spiro[1,3-dioxane-2,3''-indolin]-2''-one, spiro[1,3-dithiolane-2,3''-indolin]-2''-one, spiro[indoline-3,2''-[1,3]-oxathiolan]-2-one, and 3,3-dimethoxyindolin-2-one were also evaluated for anticonvulsant activity. Almost all compounds submitted for screening exhibited the ability to protect mice against electrically and chemically induced seizures. The ED50 and TD50 values for some of the title compounds are reported. Anticonvulsant screenings were carried out through NINCDS, NIH.This publication has 11 references indexed in Scilit:
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