Individual Renin-Aldosterone Responses of Clinically Healthy Young Japanese Men to Dietary Sodium and Posture

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Abstract
Responses to the changes in dietary Na and posture were investigated in 9 young clinically healthy Japanese males who customarily consumed a larger amount of salt than North Americans or Europeans of mixed white ethnic background. Plasma renin activity (PRA), plasma aldosterone concentration (PAC) and urinary aldosterone excretion rate (AER) differed at each end of 3-4 day spans on a control, a high-salt and a low-salt diet and of furosemide administration. PRA and PAC, determined during the upright position following the supine blood sampling, increased after 1 h of standing in each condition (P < 0.05 or more). PRA and PAC correlated well in all 4 conditions regardless of the posture (r [correlation coefficient] = 0.806, P < 0.001). There were highly significant correlations between the supine PRA or PAC and the preceding 24 h AER (r = 0.869, P < 0.001 for PRA; r = 0.855, P < 0.001 for PAC). The correlation coefficients between PRA and PAC in 9 individual subjects ranged from 0.823-0.987. The estimates of constant and slope of the regression line between PRA and PAC varied from subject to subject. The renin-aldosterone axis in response to changes in dietary Na and posture must be individually assessed.