EFFICACY OF AEROSOL, INTRANASAL AND INTRAMUSCULAR VACCINATION AGAINST SELECTED BOVINE VIRAL DISEASES

  • 1 January 1983
    • journal article
    • research article
    • Vol. 73  (4) , 375-379
Abstract
An experiment was designed to compare the efficacy of an i.m. modified live vaccine, an intranasal (i.n.) temperature-sensitive vaccine, an i.n. modified live vaccine and an aerosolized modified live vaccine (2 concentrations) to stimulate specific serum antibody and protect calves from a known viral challenge. All vaccines except the i.m. vaccine contained infectious bovine rhinotracheitis (IBR) virus and parainfluenza type 3 (PI3) virus. The i.m. vaccine and the i.n. vaccines provided excellent protection to an IBR challenge, but both concentrations of aerosolized vaccine provided only partial protection. The use of i.n. modified live vaccine resulted in IBR serum antibody (Ab) titers in all the test calves (100%), while the i.m. preparation elicited a response in only 60% of test calves and the i.n. temperature-sensitive vaccine resulted in serum Ab titers in 40% of test calves. The aerosolized vaccine induced IBR serum antibody titers in only 20% of the calves. The use of i.n. modified live and the aerosolized vaccine resulted in a greater immune response to the PI3 virus (60-80% seroconversion) than did the temperature-sensitive vaccine (20% seroconversion).

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