Calcium Sensitivity of Glutamate Release in a Calyx-Type Terminal
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- 11 August 2000
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 289 (5481) , 953-957
- https://doi.org/10.1126/science.289.5481.953
Abstract
Synaptic efficacy critically depends on the presynaptic intracellular calcium concentration ([Ca 2+ ] i ). We measured the calcium sensitivity of glutamate release in a rat auditory brainstem synapse by laser photolysis of caged calcium. A rise in [Ca 2+ ] i to 1 micromolar readily evoked release. An increase to >30 micromolar depleted the releasable vesicle pool in 2+ ] i to ∼10 micromolar would be sufficient to reproduce the physiological release pattern. Thus, the calcium sensitivity of release at this synapse is high, and the distinction between phasic and delayed release is less pronounced than previously thought.Keywords
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