Divalent Cation Dependent Conformations of Brain Calmodulin Detected by 1H NMR
Open Access
- 1 January 1986
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 40 (1) , 169-173
- https://doi.org/10.1254/jjp.40.169
Abstract
The effects of the Ca2+, Mg2+, Zn2+, Cd2+, Hg2+ and Mn2+ on the conformation of calmodulin (CaM) have been tested by using 400 MHz 1H NMR. In the aromatic region of the spectrum of CaM with a one molar ratio of cation per CaM, Zn2+, Cd2+, Hg2+ and Mn2+ induced spectral changes which were very similar to those seen for Ca2+. However, the Mg2+-induced change was different. These results are consistent with our pharmacological findings on divalent cations.Keywords
This publication has 12 references indexed in Scilit:
- Effect of calmodulin antagonists on calcium and ethanol-induced sleeping time in micePharmacology Biochemistry and Behavior, 1985
- Effects of metal cations on trifluoperazine-calmodulin interactions: induced circular dichroism studiesBiochemistry, 1984
- Modulating effects of biogenic amines on calcium and ethanol-induced sleeping timeAlcohol, 1984
- Nuclear magnetic resonance studies on calmodulin: calcium-induced conformational changeBiochemistry, 1983
- Influence of Ca2+ and Trifluoperazine on the Structure of CalmodulinEuropean Journal of Biochemistry, 1982
- CalmodulinAdvances in Protein Chemistry, 1982
- Calmodulins from Muscles of Marine Invertebrates, Scallop and Sea AnemoneThe Journal of Biochemistry, 1980
- Calcium- and magnesium-dependent conformational states of calmodulin as determined by nuclear magnetic resonanceBiochemistry, 1980
- Activation of tryptophan 5-monooxygenase by calcium-dependent regulator proteinBiochemical and Biophysical Research Communications, 1979
- Effect of calcium ion on S-100, a protein of the nervous systemBiochemistry, 1969