Sinus histiocytosis (Rosai‐Dorfman disease) clinically limited to the skin
- 1 August 1993
- journal article
- case report
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 20 (4) , 368-374
- https://doi.org/10.1111/j.1600-0560.1993.tb01278.x
Abstract
A case study of sinus histiocytosis of Rosai‐Dorfman (SH) clinically limited to the skin is presented with immunohistochemical study of the infiltrate, in both paraffin and cryostal sections. Factor XIIIa, a dendrocyte marker, was demonstrated in the cytoplasm of histiocytes. This feature had not been previously reported in this disease. In addition, the cells expressed S100 protein, CD4, CD la, GD68, and GD11c. This immunophenotyping study suggests that SH could affect the antigen‐presenting activity of Factor XIIIa cells, i.e., the skin dermal dendrocyte.Keywords
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