Stimulation of cell proliferation by histamine H receptors in dimethylhydrazine-induced adenocarcinomata
- 1 March 1978
- journal article
- Published by Wiley in Cell Biology International Reports
- Vol. 2 (2) , 199-202
- https://doi.org/10.1016/0309-1651(78)90043-7
Abstract
Cell proliferation in dimethylhydrazine-induced colonic carcinomata was stimulated by histamine and by the histamine H2 receptor agonist dimaprit and inhibited by the histamine H2 receptor antagonists Metiamide and Cimetidine but not by the histamine H1 receptor antagonist Mepyramine. In contrast histamine had no effect on colonic crypt cell proliferation in normal or dimethylhydrazine-treated rats.Keywords
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