XX/XY chimerism encountered during prenatal diagnosis
- 30 June 1988
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 8 (6) , 423-426
- https://doi.org/10.1002/pd.1970080606
Abstract
46,XX/46,XY chimerism has previously been reported in patients with abnormal sexual development, and rarely in otherwise normal individuals. We report the first postnatally documented prenatal diagnosis of whole-body 46,XX/46,XY chimerism in humans, discovered by maternal age amniocentesis. The normal male phenotype in this child creates a dilemma in prenatal counselling, since genotypic male/female chimerism cannot be assumed to imply an abnormal sexual phenotype.Keywords
This publication has 13 references indexed in Scilit:
- True hermaphroditism presenting as intermittent hematuria and groin painUrology, 1986
- Blood Group Chimeras: A ReviewVox Sanguinis, 1983
- 46,XX/46,XY chromosome complement in amniotic fluid cell culture followed by the birth of a normal female childPrenatal Diagnosis, 1982
- Investigation of genetic markers in a true Hermaphrodite with chi 46,XX/46,XYHuman Genetics, 1982
- The gonads of human true hermaphroditesHuman Genetics, 1981
- Origin of chi46,XX/46,XY Chimerism in a Human True HermaphroditeScience, 1980
- True hermaphroditism with XX/XY mosaicism: Report of a caseThe Journal of Pediatrics, 1973
- Evidence of XX-XY sex chromosome mosaicism in a child with true hermaphroditism.Journal of Medical Genetics, 1970
- Apparent masculinization of the female fetus diagnosed as true hermaphrodism by chromosomal studiesThe Journal of Pediatrics, 1962
- Human Blood-Group ChimeraBMJ, 1953