α‐Synuclein induces apoptosis by altered expression in human peripheral lymphocytes in Parkinson’s disease
Open Access
- 2 August 2004
- journal article
- fj express-summary
- Published by Wiley in The FASEB Journal
- Vol. 18 (13) , 1615-1617
- https://doi.org/10.1096/fj.04-1917fje
Abstract
Though the etiology of Parkinson’s disease (PD) remains unclear, α-synuclein (α-SN) is regarded as a major causative agent of PD. Several lines of evidence indicate that immunological abnormalities a...Keywords
Funding Information
- Ministry of Science and Technology
This publication has 63 references indexed in Scilit:
- The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementiaAnnals of Neurology, 2003
- α-Synuclein Locus Triplication Causes Parkinson's DiseaseScience, 2003
- Modulation of cell death by α-synuclein is stimulus-dependent in mammalian cellsNeuroscience Letters, 2003
- α-Synuclein, Especially the Parkinson's Disease-associated Mutants, Forms Pore-like Annular and Tubular ProtofibrilsJournal of Molecular Biology, 2002
- Sensitization of Neuronal Cells to Oxidative Stress with Mutated Human α‐SynucleinJournal of Neurochemistry, 2000
- Induction of neuronal death by α‐synucleinEuropean Journal of Neuroscience, 2000
- Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine SystemNeuron, 2000
- Aggregates from mutant and wild‐type α‐synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β‐sheet and amyloid‐like filamentsFEBS Letters, 1998
- NACP, a Synaptic Protein Involved in Alzheimer's Disease, Is Differentially Regulated during Megakaryocyte DifferentiationBiochemical and Biophysical Research Communications, 1997
- Interleukin (IL)-1β, IL-2, IL-4, IL-6 and transforming growth factor-α levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's diseaseNeuroscience Letters, 1996