Liver cell adenoma and oral contraceptives. Double tumor development

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Abstract
Liver cell adenoma (benign hepatoma) was considered a rare tumor. During the past 2 yr, 24 cases were reported in the literature. These growths occurred in young women taking oral contraceptives. Prior to the introduction of these drugs, very few cases of liver cell adenoma were reported. During the last decade, there were no reports of liver cell adenoma in males. Two estrogens and 6 progestogens are used in the preparation of contraceptive drugs. No single formulation can be implicated in the development of liver cell adenoma, since all of them were identified in patients. Liver scans were performed prior to operation in 6 of 25 patients. All scans showed space-occupying lesions. Of the radiological studies, only angiography disclosed positive findings. Available clinical data suggest that physical examination of the liver should be a necessary procedure in the follow-up of patients taking contraceptives over an extended period of time. The present case shows the need of awareness that multiple tumors can occur. Liver scans could be of assistance in evaluating these tumors before their spontaneous rupture.

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