Clonal T‐cell Lymphoproliferation Containing Epstein‐Barr (EB) Virus DNA in a Patient with Chronic Active EB Virus Infection
- 1 February 1989
- journal article
- research article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 80 (2) , 99-101
- https://doi.org/10.1111/j.1349-7006.1989.tb02273.x
Abstract
A 10-year-old boy with chronic active Epstein-Barr virus (EBV) infection developed T-cell lymphoproliferation in the terminal stage of hepatic failure. The phenotypes of the proliferating lymphocytes were CD3+, CD4+ and HLA-DR+. The genomic DNAs from these cells demonstrated two rearranged T-cell receptor .beta.-chain genes and contained the EBV genome. These findings indicate that EBV can infect T lymphocytes and might cause clonal T-cell lymphoproliferation.Keywords
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