CEREBRAL LACTATE, PYRUVATE and ATP CONCENTRATIONS, and ARTERIAL ACID-BASE BALANCE AT VARIOUS TIME INTERVALS FOLLOWING BILATERAL CAROTID ARTERY OCCLUSION IN NORMOTENSIVE and SPONTANEOUSLY HYPERTENSIVE RATS

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Abstract
Cerebral lactate, pyruvate and ATP, and arterial acid-base balance were measured in normotensive rats (NTR) and spontaneously hypertensive rats (SHR) at various time intervals following bilateral carotid occlusion. In SHR a great and progressive increase in cerebral lactate and lactate/pyruvate ratio (L/P ratio) during the first 5-6 h after occlusion was followed by a gradual decrease as the time interval increased. Cerebral ATP in SHR decreased as cerebral lactate increased and an inverse relationship was observed between lactate and ATP. In NTR there were minimal changes in cerebral lactate and L/P ratio following carotid occlusion. Bilateral carotid occlusion might cause severe ischemic damage to the brain in SHR but not in NTR. The hemodynamic factor as a cause of cerebral ischemia in hypertensives is discussed.